Mammals

Pallas's Cat: One Drug Cut Kitten Deaths From 100% to 5.88%

Two zoo collections had lost every kitten to toxoplasmosis until a 2014 antibiotic protocol cut first-year mortality to 5.88 percent, a published trial found.

Last updated: 2026-08-10

A Pallas's cat perched on a broken branch, its round pale-green pupils fully visible and its thick grey-brown fur fluffed out against the cold
Photo: Vauxford, photographed at Cotswold Wildlife Park & Gardens — CC BY-SA 4.0

Core summary

Pallas's cats (Otocolobus manul) breed poorly in zoos for a specific, documented reason: acute toxoplasmosis kills a large share of kittens before they reach a year old. Wolfgang Basso and colleagues, tracking a breeding pair at Vienna's Schönbrunn Zoo from 1998 to 2002, reported in Parasitology that of 24 kittens born, 58 percent died between the second and fourteenth week of life, mostly from acute toxoplasmosis. A wider survey across European Association of Zoos and Aquaria collections between 2006 and 2016 found first-year mortality from all causes running at 71.59 percent, with systemic toxoplasmosis confirmed by postmortem and histopathology as the leading infectious cause at 20.6 percent of deaths, according to Simon Girling and colleagues writing in the Journal of Zoo and Wildlife Medicine in 2020. A separate team led by Christiane Ketz-Riley, examining five neonatal Pallas's cats that died of toxoplasmosis with concurrent herpesvirus infection at the Oklahoma City Zoo, found defective interleukin-12 gene expression in every animal tested, evidence the species' own immune system, not just heavier exposure, may be behind the die-offs. Girling's team tested a fix at two collections that had previously seen 100 percent mortality from toxoplasmosis in kittens under a year old: starting in 2014, kittens there received a prophylactic course of the antibiotic clindamycin through the exposure window. Over the following two years, first-year mortality at those collections fell to 5.88 percent, a 67.03 percent reduction the paper reports as statistically significant with a 95 percent confidence interval of 41.76 to 78.61 percent. In the wild, the species faces a different set of pressures. Steven Ross, Bariushaa Munkhtsog, and Stephen Harris GPS-tracked 9 male and 16 female Pallas's cats across the central Mongolian steppe from 2005 to 2007, publishing in the Journal of Mammalogy in 2012; for the 13 females with sufficient location data, 95-percent-kernel home ranges averaged 23.1 square kilometers against 98.8 for males, a four- to fivefold gap the authors found was not explained by prey scarcity or season. The IUCN reassessed the species from Near Threatened to Least Concern in 2020, a change driven by better data on its range and population rather than any documented recovery, and it still lists roughly 58,000 mature individuals with a possibly declining trend.

Round pupils and 9,000 hairs per square centimeter

Per the IUCN Cat Specialist Group, Pallas's cats have a stocky, short-legged build with a head-and-body length of 46 to 65 centimeters and a bushy tail 21 to 31 centimeters long, and Smithsonian's National Zoo puts adult weight at roughly 4 to 11 pounds (about 1.8 to 5 kilograms). The build looks bigger than it is because of the coat: a figure widely cited by zoos and conservation groups, tracing to Sunquist and Sunquist's reference work Wild Cats of the World, puts fur density at around 9,000 hairs per square centimeter, among the densest of any cat species, with the hair on the underparts running nearly twice as long as on the back.

Two other traits set the species apart from most other small cats. Per the Smithsonian's National Zoo, Pallas's cats have round pupils rather than the vertical slits seen in most felids, a feature rare enough among cats that it stands out on sight, and researchers there describe the round shape as useful for judging distance. When threatened, the cat doesn't run; it flattens its body against the ground and freezes, letting its frosted grey-and-tan coat blend into the rock and scrub of its Central Asian range. Its body is too low and too stocky to outrun much of anything, so it doesn't try. A fishing cat uses stillness to hunt, crouching motionless at a riverbank until a fish surfaces; the Pallas's cat uses the same tool for the opposite job, holding still to disappear rather than to strike.

A Pallas's cat standing on a rock, its stocky body, low-set round ears, and dense mottled fur visible against a wooded background
Photo: Dick SmitCC BY-SA 2.0

A breeding pair, 24 kittens, and a 58 percent death rate

Wolfgang Basso and colleagues published the clearest early account of the problem in Parasitology in 2005: a single breeding pair at Vienna's Schönbrunn Zoo produced 24 kittens between 1998 and 2002, and 58 percent of them died between the second and fourteenth week of life, mostly from acute toxoplasmosis. That wasn't an isolated cluster. Simon Girling and colleagues, writing in the Journal of Zoo and Wildlife Medicine in 2020, reported that across European Association of Zoos and Aquaria institutions between 2006 and 2016, Pallas's cats died at a rate of 71.59 percent from all causes in their first year of life, with systemic toxoplasmosis, confirmed by postmortem examination and histopathology, the single largest infectious cause at 20.6 percent of deaths.

The species appears unusually vulnerable to a parasite, Toxoplasma gondii, that most cats and most mammals carry without incident. Christiane Ketz-Riley and colleagues, examining five neonatal Pallas's cats that died of toxoplasmosis with a concurrent herpesvirus infection at the Oklahoma City Zoo, reported in the Journal of Zoo and Wildlife Medicine in 2003 that blood work on the animals showed defective interleukin-12 gene expression in every cat tested and reduced lymphocyte responses in others, pointing to an immune dysfunction built into the species rather than an unusually harsh environment or exposure route. Fennec foxes carry a comparably fixed trait: as an earlier FactCrumbs piece on fennec fox kidneys covers, their concentrating kidneys can't be replicated by captivity no matter how the enclosure is designed. Pallas's cats' apparent vulnerability to Toxoplasma reads the same way, a trait a zoo has to work around, not one it created.

A prophylactic antibiotic, tested at two collections since 2014

Girling's 2020 paper describes what happened when two collections that had previously recorded 100 percent mortality from toxoplasmosis in kittens under a year old changed their protocol. Starting in 2014, kittens at those two collections received a prophylactic course of the antibiotic clindamycin covering the periods of highest Toxoplasma exposure risk, applied to a cohort of 17 kittens. Over the two years that followed, first-year mortality at those collections fell to 5.88 percent among treated animals, a 67.03 percent reduction the paper reports as statistically significant, with a 95 percent confidence interval of 41.76 to 78.61 percent on the size of the effect.

The paper doesn't claim the underlying immune vulnerability identified by Ketz-Riley's team has been explained or fixed; clindamycin works by suppressing the parasite during the window kittens are most exposed to it, not by correcting whatever makes Pallas's cats susceptible in the first place. What changed is that a specific, previously near-total cause of death in captive kittens now has a documented countermeasure that two real collections actually tried, not just a fix proposed on paper.

In Mongolia, male ranges run four to five times larger

Wild Pallas's cats face a different set of pressures than captive ones. Steven Ross, Bariushaa Munkhtsog, and Stephen Harris GPS-tracked 9 male and 16 female Pallas's cats across the central Mongolian steppe between 2005 and 2007, publishing their results in the Journal of Mammalogy in 2012. For the 13 females with enough location fixes to calculate a reliable estimate, 95-percent-kernel home ranges averaged 23.1 square kilometers; for the 9 males, the average was 98.8 square kilometers, with individual male ranges spanning as wide as 20.9 to 207.0 square kilometers. That's roughly a four- to fivefold gap between the sexes, and the study's authors found it held regardless of prey density or season, ruling out the simplest explanation that males just have to work harder to find food.

The IUCN reassessed the species from Near Threatened to Least Concern in 2020. The assessment itself credits better survey data for the change, not any measured increase in cat numbers on the ground, and the current listing estimates roughly 58,000 mature individuals with a population trend that may still be declining. Regional threats named in the assessment include direct poaching, secondary poisoning from rodent-control campaigns that target the pikas and ground squirrels the cats depend on for prey, and habitat fragmentation from mining and infrastructure development across its Central Asian range. A species can be reclassified as less at risk on paper, in other words, without a single one of the pressures documented on the ground having eased.

Frequently asked questions

Why do Pallas's cat kittens have such a high death rate in zoos?

Acute toxoplasmosis, an infection from the parasite Toxoplasma gondii. A 2005 study of a Schönbrunn Zoo breeding pair found 58 percent of 24 kittens died from it between weeks two and fourteen of life, and a wider 2020 survey across European Association of Zoos and Aquaria collections (2006-2016) put first-year all-cause mortality at 71.59 percent, with toxoplasmosis the leading infectious cause. A 2003 study found defective interleukin-12 gene expression in affected kittens, evidence the species carries an unusual immune vulnerability to the parasite rather than just facing heavier exposure to it.

Has anything worked to reduce Pallas's cat kitten mortality in captivity?

Yes. A 2020 paper in the Journal of Zoo and Wildlife Medicine reported that two zoo collections that had previously seen 100 percent toxoplasmosis mortality in kittens under a year old began giving a prophylactic course of the antibiotic clindamycin in 2014. Over the following two years, first-year mortality at those collections, among 17 treated kittens, fell to 5.88 percent, a statistically significant reduction.

Do Pallas's cats really have round pupils?

Yes. Per Smithsonian's National Zoo, Pallas's cats have round pupils rather than the vertical slits seen in most other small cats, a trait rare among felids that researchers there note is useful for judging distance.

How much farther do male Pallas's cats range than females?

About four to five times farther. A 2012 GPS-tracking study in the Journal of Mammalogy, covering 9 males and 16 females (13 with sufficient data for the estimate) across the central Mongolian steppe from 2005 to 2007, found 95-percent-kernel home ranges averaging 98.8 square kilometers for males against 23.1 for females, individual male ranges reaching as high as 207.0 square kilometers.

Is the Pallas's cat endangered?

No, it is currently listed as Least Concern by the IUCN, a reassessment made in 2020 from its previous Near Threatened status. The change reflects improved data on the species' range and population, not a documented recovery, and the assessment still estimates roughly 58,000 mature individuals with a population trend that may be declining, citing poaching, secondary poisoning from rodent-control programs, and habitat fragmentation from mining as ongoing regional threats.

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